Shedding new light on the eye
Diagnosing eye diseases
The Biophotonics group are creating an all-optical technique to measure elastic properties of vitreous humour in an eye using Optical Coherence Elastography (OCE).
This new method could be useful for diagnosing and monitoring eye-related diseases that change the elasticity of the vitreous humour like diabetic retinopathy or age-related macular degeneration.
Using group velocity dispersion to differentiate tissue in-vivo
The group have developed a method that enables differentiation of materials by their Group Velocity Dispersion (GVD) value and can be applied in various biological studies.
The determination of GVD is based on the estimation of the difference in the thickness of a material calculated from two images obtained for different spectral ranges.
Initially two separate light sources were used, whereas it is now proposed to apply a filter-based, numerical procedure that synthesises two spectra centered around different wavelengths from one sufficiently broadband spectrum.
This method requires no modifications to the system and can be easily used for every OCT data-set acquired from a Fourier domain system employing light source of sufficiently broad spectral bandwidth.
Since OCT imaging is often performed on samples of considerable depths, the group also aim to develop a Spectral OCT system which would enable long imaging range.
Funding and collaborators
Dr Eshan Vaghefi
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Associate Professor Frederique Vanholsbeeck
In addition to developing state-of-the-art imaging capabilities, Frederique has successfully worked towards improving the OCT technique. In particular the development of original signal processing methods using OCT to identify tissues of different natures, adding a layer of functional information to the structural image. Visit the link to contact Frederique.
Dr Sylwia Kolenderka
Sylwia's research is focused on developing new functional extentions of Optical Coherence Tomography based on chromatic dispersion of light propagation in the sample. The methods being developed are software based and can be used for any Fourier Domain OCT. They require no modification in the experimental system and can be used to realise multimodal imaging where complimentary information about a sample is obtained during a single examination. Please visit the link to contact Sylwia.