OCT for Biofilm Research
Hendrik's MSc project aimed to develop a Spectral Domain Optical Coherence Tomography (SD-OCT) system with a high-resolution sensitivity for analysing biofilms and biofilm phantoms. The development encompassed designing system optics, developing a LabVIEW program for system operation, and Python-based data processing. Experiments included micrometre-scale measurements within biofilm growth enclosures, Doppler velocimetry of fluid flow through microfluidic tubing, wave propagation analysis, and vibrometric and elastographic measurements using piezoelectric crystal-induced motion. The work completed throughout this project aimed to evaluate the feasibility of integrating the OCT system with Optical Tweezers (OT) and to establish a protocol for further biofilm analysis using this combined optical system.
Hendrik Nieuwboer
MSc in Physics
Funding and collaborators
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Craig Steed
PhD Student
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Associate Professor Frederique Vanholsbeeck
In addition to developing state-of-the-art imaging capabilities, Frederique has successfully worked towards improving the OCT technique. In particular the development of original signal processing methods using OCT to identify tissues of different natures, adding a layer of functional information to the structural image. Visit the link to contact Frederique.
